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Simon
Vermeir
  • Artificial IntelligenceBioinformaticsDrug DesignDiffusion ModelsGuidance
    2025

    Optimizing Diffusion Models For Generative Antibody Design

    Negative guidance with an auxiliary model to improve sample quality without increasing dataset size.
    Started from existing model. Introduced guidance technique from image diffusion. Improved sampling strategy and trained an auxiliary model on synthetic data using a custom dataloader with LMDB for efficient access. Applied negative guidance at inference to steer generation toward higher-quality samples. Evaluated using RMSD, AAR, and ESM-2 Perplexity Pseudo Log Likelihood for biological plausibility.

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  • Web-appMobile-appReactFlaskMicroservicesProject Management
    2021

    Funnler

    Funnler is a virtual queueing platform for large events: a React Native attendee app plus a React organizer dashboard with simulations and live queue insights, backed by scalable Python microservices on Kubernetes. I led the eight-person team and contributed to the front-end, scheduler, and product design.

    antibody graphic
  • Operations ResearchLocal SearchSchedulingJava
    2020

    The Job Sequencing And Tool Switching Problem

    Sequence jobs so that you minimize the amount of tool switches you need to do. Solved using local search.
    Introduced a novel local search operator that does ruin and recreate. It ruins and recreates by using a strategy that clusters jobs and best inserts local sequences. Aided by a well established constructive heuristic and guided using simulated annealing as meta heuristic.

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  • AI ExplainabilityDeep LearningData VisualizationWeb App
    2025

    Imagenet Data Insights with VGG16

    Interactive Dash app to inspect VGG16: layer activations, per-layer t-SNE embeddings, and class heatmaps (CAM/Grad-CAM), on ImageNet subsets.

    antibody graphic
ML and DL·Generative models·Computational biology·Optimization·Operations research·Algorithm design·Data pipelines·Scientific software·Web apps and interfaces·
ML and DL·Generative models·Computational biology·Optimization·Operations research·Algorithm design·Data pipelines·Scientific software·Web apps and interfaces·

simon@simonvermeir.com

Created by Simon Vermeir